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PEGylation the covalent attachment of polyethylene glycol (PEG) chains via a succinyl linker surrounds the peptide with a steric hydrophilic shield that dramatically increases hydrodynamic radius, reduces renal filtration, and provides protection from proteolytic degradation
Role of pancreatic transcription factors in maintenance of mature -cell function
TABLE 525 Reactions of Importance in Relation to Oxidative Stress in Blood Cells and Various Tissues Superoxide is formed (reaction 1) in the red blood cell by the auto-oxidation of hemoglobin to methemoglobin (approximately 3% of hemoglobin in human red blood cells has been calculated to auto-oxidize per day)
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Threat of substitute 5.2.4
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